Treatment for chronic cannabis pain
A team from the Pompeu Fabra University starts a project to obtain a new analgesic drug to improve the treatment of chronic pain.
The team of researcher Rafael Maldonado has discovered that the effects of cannabis are independent of its harmful effects. And this project aims to develop a drug that takes advantage of the benefits but without side effects.
According to Maldonado, at present we already have effective anti-inflammatory drugs to treat mild pain. And also of opiates to treat severe type pain. But the problem is in chronic intermediate pain since there is no drug to treat it. This type of pain affects 50 million people in Europe. Examples of this type of pain can be osteoarthritis or neuropathic pain that thanks to this project could find a solution in cannabis.
The drug is in the experimental phase of development and is based on one of the main cannabis cannabis, THC (tetrahydrocannabinol).
The analgesic effects of cannabis are based on the action of THC on a molecule (cannabinoid receptor) type 1 or CB1. While the undesired effects are based on the action of THC on a structure formed by two bound receptors, a CB1 assembled to a serotonin receptor.
The key was finding a molecule capable of breaking the binding between the CB1 receptor and the serotonin receptor. This would make it possible to take advantage of the analgesic effects of cannabis without its undesired effects. In this way THC could no longer cause, for example, cognitive impairment.
And Maldonado and his team have developed a molecule that breaks the union between the receptors.
Waiting for clinical trials with people with chronic pain
Tests with mice have already shown that the new molecule if injected into the blood reaches the brain. And now the goal is to develop a drug that can be administered orally or nasally. Maldonado hopes to start a clinical trial in people with chronic pain in hospitals in the Barcelona area.
Source: La Vanguardia
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DOES AN APPLICANT NEED MUNICIPAL APPROVAL BEFORE RECEIVING A RETAIL CANNABIS LICENSE? Yes, municipal approval is necessary prior to the AGLC will subject a retail cannabis license. Applicants must get in contact with their intended municipality to learn requirements regarding municipal retail cannabis legislation, zoning requirements, land-use limitations, and place requirements concerning how near a retail store can be into a provincial medical care centre, college, or parcel of property designated as a school book.
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